Page 10 - KBM_1_2024_WEB

Table 1. Main EQA studies using commutable control materils in last five years

Analyte Citation Number of IVD Number of EQA Number of labs Bias (%)
HbA 5 24 12 23166 4.4
1c
Creatinine 6 7 4 567 -8 to 4
Glucose 7 4 2 58 -2 to 3.8
Table 2. APS values (%) - required limits for EQA programs - demonstration for routine blood serum analytes with an emphasis
on markers of diabetes, chronic kidney disease and risks of dyslipidemia

ADLM
SEKK CZ CLIA 2024 Rilibäk 2023 RCPA-QAP SKLM 2023 The EFLM
Analyte/EQA 2024
2024 USA Germany 2024 Australia Netherlands BVD* 2023
USA
Creatinine 13 10 20 8* 8.3 7.4
Albumine Urin 21 - 26 20 46 -
Cholesterol 9 10 13 6 8.7 8.8 9
Triacylglycerides 18 15 16 12 9.3 27 15
LDL-cholesterol 20 20 - 10 11 13.7 12
Glucose 8 8 8 8 7 6.5
Glycated Hemoglobin HbA 1c 10 8 8 8 8 3.1
ALT 15 15 21 12 16.1 16.1
Albumine Blood serum 10 8 20 6 8 3.4
IgA 14 20 20 10 9.8 9.8
IgG 13 20 18 10 7.3 7.3
IgM 18 20 26 15 17.1 17.1
Potassium cation 7 6 to 10 8 5 4.9 4.8
Sodium cation 5 2.5 to 3.5 5 2 to 3 2.9 1**
Troponine I 27 30 33 20 18 19
Troponine T 22 30 33 20 23 18
Calcium total 8 10 10 4 6.1 2.3/3.4***
Chloride 7 5 8 3 5 1.3/2
Phosphate 15 10 16 8 8.5 9.7
Urea 15 9 20 12 7.1 17.8
Uric Acid 12 10 13 8 5.8 12.8
Protein total 9 8 10 5 7.8 3.5/5.2***
GGT 21 15 21 12 9.9 18.9
LD 18 15 18 8 12.9 7.7
α-AMS 15 20 - 10 10 13.2

*Biological variation database- desirable values
** Minimum APS value according to the EFLM BVD
*** Desirable/minimum value according to EFLM BVD
Table 3. Several examples of APS values for routine immunochemical methods with a low level of harmonization

Rilibäk 2023 RCPA-QAP 2024 SKLM 2023 The
Analyte/EQA SEKK CZ CLIA 2024 USA EFLM
Germany Australia Netherlands
TSH 14 20 24 20 11.6 24.6
fT4 13 15 20 12 15.1 6.3
PSA 15 20 25 8 15.9 16.2
Testosteron 30 30 35 15 16.3 16.5
Estradiol 30 30 35 25 18.2 17.3

8 Klinická biochemie a metabolismus 1/2024