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Table 1. Systematic review of recent publications on MDW
Number
Year Cut-off value Results
of Patients
Sepsis: AUC(MDW) = 0.79
Crouser, E., et.al AUC(MDW + WBC) = 0.89
1 2017 1320 at the ED 20.5 (K EDTA)
[18] 2 SIRS: AUC(MDW) = 0.74
AUC(MDW + WBC) = 0.79
Sepsis-2: AUC(MDW) = 0.79
Crouser, E., et.al
2 2019 2212 at the ED 20.5 (K EDTA) Sepsis-3: AUC(MDW) = 0.73
[21] 2
Sepsis-2: AUC(MDW + WBC) = 0.85
Polilli, E., et.al Sepsis: AUC(MDW) = 0.87
3 2020 260 at the ED 22.0 (K EDTA)
[22] 3 AUC(PCT) = 0.88
MDW > 20:
(Sepsis-2) Sensitivity = 74.0 %
Crouser, E., et.al
4 2020 2158 at the ED 20.5 (K EDTA) (Sepsis-2) Specificity = 72.0 %
[23] 2
(Sepsis-2) PPV = 36.5 %
(Sepsis-2) NPV = 92.7 %
AUC(MDW) = 0.91
Sensitivity = 98.0 %
Ognibene, A., et. al Covid-19
5 2020 147 at the ED Specificity = 65.0 %
[34] 27.3 (K EDTA)
2 PPV = 51.9 %
NPV = 98.6 %
Sepsis-2: AUC(MDW) = 0.964
Agnello, L., et.al
6 2020 2215 at the ED 23.5 (K EDTA) Sepsis-2 Sensitivity = 92.0 %
[24] 3
Sepsis-2 Specificity = 92.9 %
Reference intervals (RI):
16.22 – 23.15 (non-parametric method
without outlier removal)
16.44 – 22.99 (non-parametric method with
outlier removal)
16.29 – 22.98 (robust method without outlier
Agnello, L., et.al
7 2020 486 (K EDTA) removal)
[25] 3
16.50 – 22.67 (non-parametric method with
outlier removal)
16.19 – 23.24 (Harrell-Davis bootstrap
method without outlier removal)
16.43 – 22.93 (Harrell-Davis bootstrap
method with outlier removal)
30.9 Sepsis
Agnello, L., et.al
8 2020 96 in the ICU 20.3 No sepsis Pilot study
[19]
(K EDTA)
3
ED patients for MDW > 23.5
Sensitivity: 90.9 %
Specificity: 92.9 %
Agnello, L., et.al 2215 at the ED 23.5 for ED patients AUC = 0.964
9 2021
[26] 82 in the ICU 23.9 for ICU patients ICU patients for MDW > 23.9
Sensitivity: 95.7 %
Specificity: 79.7 %
AUC = 0.937
MDW > 24.63
Piva, E., et.al 24.63 Sensitivity: 66.88 %
10 2021 506 in the ICU
[27] (K EDTA) Specificity: 77.79 %
3
AUC = 0.785
Sepsis Index ≥ 1
Sensitivity: 92.0 %
Agnello, L., et.al Specificity: 94.7 %
11 2021 2215 at the ED Sepsis Index ≥ 1
[28] AUC = 0.964
PPV = 0.420
NPV = 0.997

8 Klinická biochemie a metabolismus 1/2022